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y Lynn Toohey, PhD The recent craze over weight-loss drugs Ozempic and Wegovy (higher dose of the drug) led to headlines such as, Weight-Loss Drugs Taking Hollywood by Storm. However, they also led to headlines such as, We Wouldnt Have Ozempic Without Gila Monsters Their Hunger-Regulating Venom Inspired Weight-Loss Drugs. 1 The forerunner to these drugs exenatide generated this headline close to 20 years ago: Diabetes Drug Made from Lizard Spit Approved. 2 Thats right

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Firstly, the increase in FGF19 levels inhibits hepatic gluconeogenesis by suppressing the transcriptional activity of CREB, which is a key regulator of PGC-1

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