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Exercise performance: May improve exercise capacity and reduce fatigue, particularly in carnitine-deficient populations [5]

Protein expression was detected by SuperSignal West Pico Chemiluminescent substrate (Thermo, Waltham, MA, USA) and Fujifilm LAS-3000 (Fujifilm, Tokyo, Japan)

Korbut R, Marcinkiewicz E, Cielik K, Gryglewski RJ

Frontiers in Aging Neuroscience, 11, 257

However, metformin is not appropriate for people with certain other medical conditions, such as kidney disease, congestive heart failure, metabolic acidosis, and liver issues

yet these agents may favor an increase of lean mass and mimic an energy deprivation state with increased ketogenesis (i.e., BHB) through increased circulating GH levels ( Figure 1 )