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Because melanin overproduction is the primary cause of hyperpigmentation, glutathione is an excellent treatment for skin discoloration and hyperpigmentation

[60] In mice, the extracellular superoxide dismutase (SOD3, ecSOD) contributes to the development of hypertension

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Activated adenylate cyclase leads to increased production of cAMP and the concomitant activation of cAMP-dependent protein kinase (PKA) with the result being phosphorylation and activation of hormone-sensitive lipase