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The SURMOUNT-OSA trial showed a 63% reduction in sleep apnea severity, and up to 51.5% of participants achieved disease resolution

Hormonal medications (e.g., certain birth control methods): Can affect appetite, fluid retention, or fat distribution in some individuals

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However, evidence on the cardiovascular benefits of tirzepatide is only emerging and no randomized study has directly compared it to semaglutide 16,17

Dose Adjustment : If fatigue is severe or persistent, healthcare providers may consider slowing the dose-escalation schedule (FDA labeling allows for flexible titration with 2.5 mg increments no more frequently than every 4 weeks) or maintaining a lower maintenance dose that balances therapeutic benefit with tolerability