According to the research of YANG W et al
Its important to approach GLP-1 therapy judiciously, when its clinically appropriate, with the intent to eventually transition people away from perpetual dependence on these medications through lifestyle interventions such as healthy eating and physical activity
An analysis of nearly 10,000 people taking semaglutide drugs found they lost on average 10.2-13.2% of baseline weight over 12 months.(8) Its important to note that GLP-1 clinical trials employ run-in periods where non-adherent participants are excluded.(9) Real world patients face many barriers to consistent adherence, including side effects, injection anxieties, medication costs and behavioral challenges
Their similarities often lead to comparisons, but their development history, approved uses, and available clinical evidence are quite different
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