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Human VIP+ enteric neurons in the submucosal plexus and myenteric plexus express the GLP-2R (Guan et al., 2006) (Table 3)

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Incubation of 50 m rosmarinic acid with B16 melanoma cells for 48 h resulted in a significant increase in melanin content and tyrosinase protein expression, the mechanism being that rosmarinic acid induces melanin synthesis by activating the PKA/CREB signaling pathway via phosphorylation (Shomirzoeva et al., 2019)

Each pre-filled pen contains 4 weekly doses, enough for a month of treatment when used once a week