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Dose reduction or temporary discontinuation was allowed for safety, particularly in the setting of hyperkalemia
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Weight loss in patients with obesity but no HF is associated with effects that would be expected to reduce symptom severity and improve exercise function in patients with HFpEF, including reversal of hypertrophic chamber remodeling, improvement in ventricular mechanics and reductions in hemodynamic congestion 13,14
This allows the medication to largely leave your system, reducing the risk of compounded side effects
M., Xu X
