B12 addresses the tolerability problem
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(114) reported that pain severity, functional disability scales, photophobia, phonophobia, and nausea were significantly reduced in patients with menstrual migraine after taking vitamin E supplements (400 units daily for 5 days, starting 2 days before to 3 days after menstruation for two cycles) (114)
Because of structural changes that allow it to remain active longer, it is often associated with signaling processes involved in cell development, protein activity, and tissue maintenance