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The Nrf2 activation by hesperidin may have also contributed to reduced iron-induced oxidative stress in the mouse kidney

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Results: NA treatment did not have any impact on cell viability, while, as expected, it slightly reduced insulin secretionafter 24 h

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Hua T, Wang RM, Zhang XC, Zhao BB, Fan SB, Liu DX, et al

These minor side effects usually occur at higher doses and can often be mitigated by taking the supplement with food or adjusting the timing of consumption