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Pesenti, E., Masferrer, J., & Di Salle, E

Glatigny S, Bettelli E

Additionally, AF may occur concurrently with other rare conditions such as SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, acne), PASH syndrome (pyoderma gangrenosum, acne, suppurative hidradenitis) syndrome, and CAH (congenital adrenal hyperplasia), highlighting the importance of comprehensive clinical evaluation (5)

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Where the molecules triple mechanism might differ from single or dual agonists on safety is one of the open questions, not a settled one

The bodys ability to produce glutathione naturally declines with age