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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Riba A., Deres L., Sumegi B., Toth K., Szabados E., Halmosi R

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration

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PMC 3155927

Introducing microbes

C9SN modifies the immunosuppressive tumor microenvironment (ITM) by impeding glutamine metabolism on one hand, polarizing M2-TAMs to M1-TAMs, which in turn recruits and activates CTLs, while on the other hand, C968 in the nanoaugmentation amplifies the intracellular oxidative stress by inhibiting glutamine metabolism-mediated GSH deprivation, which results in severe cell death, and also enhances the immunogenic cell death (ICD) effect [122]