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Users who've run both report that DES produces less water retention and fewer hypoglycemic events but requires multiple daily injections (34x per day) to maintain stable signaling

doi: 10.1007/s12325-025-03289-2 570 Fredua-AgyemanMLarbiEA

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However, the studies were not designed to definitely establish the risk of use of metformin HCl during lactation because of small sample size and limited adverse event data collected in infants

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