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Any decision to begin at a higher dose should be made by a clinician based on individual circumstances and previous experience with similar treatments

Patients should start gradually and build up intensity to avoid symptom flare-ups

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Sin embargo, estos estudios presentan limitaciones metodolgicas significativas, incluyendo tamaos de muestra pequeos, falta de estandarizacin de dosis, alta heterogeneidad entre estudios y variabilidad en las poblaciones estudiadas

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