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GLP-1R agonists (e.g., exendin-4 and liraglutide) reduce APP expression and processing in the brains of AD model mice through the activation of GLP-1R, decrease A protein production and plaque aggregation, and thus improve their spatial memory capacity (Wang et al., 2016)

In contrast, its intestinal microbial metabolite, urolithin, possesses better biological activity and higher bioavailability [173]

Final Thoughts on Treating Menopause Belly Fat with GLP-1s and HRT I hope this has led you to the beginning of a new perspective

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Medicines that act on gut hormone receptors can commonly cause digestive side effects, especially when treatment starts or when the dose is increased

CYP1A1 activity increases 4.6-fold, leading to excessive free radical production and subsequent DNA damage, while CYP3A4 expression decreases by 68%, severely impairing steroid hormone metabolism (43, 44)