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Abstract Obesity is accompanied with accumulation and pro-inflammatory polarization of macrophages in adipose tissue (AT), leading to systematical inflammation and insulin resistance

For many, GLP-1 injections represent a less invasive, medically supervised alternative that still offers substantial weight loss

Exenatide (EXE) (2 mg weekly), Dapagliflozin (DAPA) (10 mg daily), Exenatide + Dapagliflozin (2 mg weekly/10 mg daily), Dapagliflozin (10 mg) + Metformin (MET) (2000 mg extended release daily), or Phentermine (7.5 mg)/Topiramate were given to the patients for 24 weeks (46 mg extended release daily)

The trick is to make sure its cooked for a really long time so all of the collagen soaks out of the bones, says Gellman

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At the same time, this was an observational study, so the results should be viewed as encouraging and hypothesis-generating rather than practice-changing on their own