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In the USA, dedicated resources, including strategies focused on diverse recruitment and retention and outreach efforts, are being implemented to include participants from ethnic and racial minorities, as well as those from different socioeconomic backgrounds, who are usually underrepresented in AD clinical trials [67]

[9] [10] However, older adults with severe heart failure or significant renal impairment require careful assessment, as dehydration from gastrointestinal side effects may exacerbate kidney function decline and increase acute kidney injury risk