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Higher circulating trimethylamine N-oxide aggravates cognitive impairment probably via downregulating hippocampal SIRT1 in vascular dementia rats

All surface areas were calculated based on the crystal structures using freeSASA 48

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Although an inverse relationship between blood HDL-C concentration and the risk of cardiovascular events has been demonstrated repeatedly, studies concerning agents increasing its concentration (i.e., niacin or cholesterol ester transfer protein (CETP) inhibitors) have not yet demonstrated their beneficial effects in terms of cardiovascular risk reduction [77, 78]

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