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For example, SHPRH-146aa limits the PCNA protein level and thereby glioblastoma cell proliferation by protecting full-length SHPRH, which is the ubiquitin ligase E3 of PCNA (Zhang et al, 2018a)

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We have shown that RGDV infection activates the expression of leafhopper sperm-specific HongrES1, which is essential for sperm maturation in the male reproductive organ and contributes to paternal virus transmission 13