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M.KlieS.CaldanaC.DegenkolbeT.WillmitzerL.HoefgenR

Moreover, carotenoids that do not function as substrates (e.g., canthaxanthin, zeaxanthin) interfere with retinol conversion (by inhibiting carotene dioxygenase), whereas protein-energy malnutrition hampers retinol circulation (by affecting plasma levels of retinol-binding protein)

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Nrf2, Nuclear factor erythroid 2-related factor 2

Such changes can affect the metabolism of medications that utilize this pathway, affecting their efficacy during and after the menopausal transition

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