Although no statistically significant difference in baseline GLP-1 level was noted between responders and non-responders, it seems that the responders with more symptoms of metabolic syndrome (total fat, visceral fat and insulin resistance) react with higher insulin after GLP-1 infusion
For context, retatrutide vs semaglutide data shows retatrutide producing roughly 50% more weight loss than the highest approved semaglutide dose
Furthermore, a more recent study in 2007 by Safarinejad et al
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doi:10.1136/bmj.q1645 Wilding JPH, Batterham RL, Calanna S, et al
Why does the AOD-9604 peptide not raise IGF-1 like full-length hGH does