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GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (6, 7, 39, 4353)

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Ala16Val mutation in Mn-SOD changes the secondary structure of the protein, which may affect the targeting of the protein to mitochondria [63]

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