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Targeting glutamine transporters as a treatment for cancer Cancer cells require an abundant supply of glutamine from the extracellular milieu

Murine Acy3 shows 43% and 5% amino acid sequence identity with murine aspartoacylase and Acy1, respectively

The PEG chain substantially extends half-life by reducing proteolytic degradation, enabling extended time-course studies not achievable with non-PEGylated MGF

The liposome then splits open and the glutathione inside is emptied into the cell

Conversely, butyrate may promote ferroptosis in specific contexts

Biopsy #1 was a historical biopsy performed at the time of diagnosis of the proband, over 5 years ago for research purposes