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Elevated lactate implies potential mitochondrial dysfunction, with an increased reliance on glycolysis for ATP production (Mathew et al., 2009

additionally, more research is required to investigate differences between NAD + modulators within different tissues, different models or pathologies, administration or exercise regimens, and how to successfully translate these findings to humans, while several clinical trials have already been conducted

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14 , e8124 (2018)

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Inhibition of the JNK signaling pathway leads to a decrease in cisplatininduced apoptosis, while overexpression of c-jun increases the sensitivity of cells toward cisplatin (Potapova et al ., 1997)