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1 Irrespective of the specific urate-lowering therapy (ULT) selected, fundamental principles entail commencing treatment concurrently with prophylaxis and initiating with a conservative dosage, followed by systematic monitoring of serum uric acid levels and subsequent dose adjustment until the therapeutic target is attained

In addition, D 3 R desensitization, which was abolished following USP33 knockdown, was restored by the co-expression of WT-USP33 but not by the co-expression of T154A-USP33 (Fig