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Ethics declarations Ethics Approval and Consent to Participate All experimental procedures of this study were conducted under ethical committee supervision of Iran University of Medical sciences (Tehran, Iran) that was in accordance to NIH guidelines for the care and use of laboratory animals

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A healthy and balanced diet, regular physical activity, and other lifestyle modifications are essential for achieving sustainable weight loss

Standard titration protocol This is closest to what the phase 2 clinical trial used

On Day 1, blood glucose levels differed significantly among the four groups (Kruskal-Wallis H = 27.24, p 0.05)

#2 I've been on it 5.5 weeks (1mg/week, split into two doses for the first 4.5 and upped to 1.4mg/week on Tuesday) and no appreciable impact to HR