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393 Direct mitophagy enhancers include urolithin A, which induces mitophagy and improves mitochondrial function in AD and PD models, 394 and kinetin and its analog MTK458, which stabilize PINK1 and enhance Parkin-mediated mitophagy in PD models

The International Journal of Biochemistry & Cell Biology, 37 (8), 1727-37

2025 kjzy011) and the Central Government Guiding Local Science and Technology Development Fund Project (Grant No

The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51

More substantial improvements , such as enhanced firmness and reduced discoloration, often develop between 48 weeks