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Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress

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Age-related physiological changes, including reduced renal function, altered drug metabolism, and increased frailty, necessitate individualised treatment approaches

This study screened the heterozygous diploid deletion with a derivative of tenovin to show that sir2 deletion strains manifested tenovin-induced haploinsufficiency

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