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The GlyNAC protocol (NAC + glycine) alone has been shown to restore glutathione to youthful levels in older adults within 2-4 weeks

Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site

doi: 10.4161/psb.6.2.14701

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