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however, no substantial progress has been made in clinical practice

Higher-purity peptides (98%+ by HPLC) contain fewer synthesis by-products and truncated sequences that can act as nucleation sites for aggregation and degradation

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Pegylated arginine deiminase (ADI-PEG-20), which duplicates arginine and increases tumor stress and cytotoxicity, increased the number of tumor-infiltrating T cells in phase I studies and was safe in combination with anti-PD-1 antibody, but with an increased risk of neutropenia

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