Normally, NAPQI is rapidly de-toxified by conjugation with glutathione, but the pathway can become saturated as a result of overdose, combination with alcohol, or in individuals with polymorphisms in the P450 metabolizing enzymes
Am J Physiol Endocrinol Metab 2007
Gao Y, Zhang H, Tang L, Li F, Yang L, Xiao H, et al
Elevated vitamin B12 (cobalamin) levels in the blood are often discovered incidentally during routine blood tests, as high B12 itself rarely causes direct symptoms
Daru 18(3):155162 Chatterjee S (2016) Oxidative stress, inflammation, and disease
In addition to dietary supplements, alcoholics with moderate malnutrition might benefit from treatment with anabolic steroids