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1,2 The effect is to stimulate the hepatic breakdown of the complex carbohydrate glycogen to glucose (glycogenolysis), synthesis of glucose (gluconeogenesis), suppression of glycolysis (the anaerobic breakdown of glucose), and inhibition of glycogenesis (the formation of glycogen)

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Compared with that of the ITP condition, the scrambled ITP control strongly inhibited IR protein-coumarin fluorescence and weakened the FRET signal from fluorescein isothiocyanate (FITC) emission (Supplementary Fig