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The change in neuronal signal transduction caused by peripheral nerve injury is an important pathological basis for the occurrence and continuous progress of NP, in which the abnormal expression of pain sensors is the main factor, especially the change in the expression of sensory neurons in the DRG of the pain upload pathway [97,98]

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Studies suggest that intrinsic resistance can be caused by (a) inherited genetic alterations that result in most of the tumor cells having reduced responses to chemotherapy and target drugs

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