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Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Instruction may be provided for at-home administration when appropriate

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This process is mediated by the system xc antiporter, composed of solute carrier family 7 member 11 (SLC7A11, also known as xCT) and its chaperone solute carrier family 3 member 2 (SLC3A2, also known as CD98)

Early studies focused on single-hormone pathways, particularly GLP-1