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SNAP-tag is a protein tag that forms a highly stable covalent thioether bond with a fluorophore or other substituent group when appended to benzylguanine

That said, if any adverse effect is suspected to be dose-related, the dose can be reduced

Take, for example, Breckas partnership with BodyHealth

The levels of ATP5F1, Prohibitin-2 and ETFDH were significantly increased in female livers treated with ibuprofen (Supplementary Figure 2C)

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And a C18 fatty diacid chain attached at position 26 allows the peptide to bind to albumin in the bloodstream, which slows its clearance and gives it a half-life of approximately seven days