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+ The SURMOUNT-1 trial the pivotal clinical trial for tirzepatide (Zepbound, Mounjaro) used the same 500 calorie daily deficit protocol as the semaglutide trials

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A Systematic Review

Indeed 5-HT 2C agonists appear to regulate DA neurotransmission by decreasing DA cell activity in the VTA, a region also rich in GHSR1a expression (Di Giovanni et al., 2000)