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Last Published 12.01.2025 Effective Date: 12.01.2025 This policy addresses the use of Zolgensma (onasemnogene abeparvovec-xioi) for the treatment of spinal muscular atrophy (SMA)

Patients enrolled in the PIONEER 2 [15], PIONEER 3 [16], SUSTAIN 2 [17], and SUSTAIN 8 [18] trials had type 2 diabetes that was uncontrolled by metformin (with or without sulfonylurea) and were treated with an additional oral/subcutaneous GLP-1RA (semaglutide), oral SGLT-2i (empagliflozin/canagliflozin), or oral DDP-4i (sitagliptin)

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doi:10.1016/j.cmet.2017.07.011 52

These are often mild and temporary

Timing: Once weekly on the same day each week Any time of day (morning or evening) With or without meals Consistent weekly schedule recommended.[fidelitymedicalclinic] How Should I Administer Tirzepatide