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This study aims to deliver monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA), a novel next-generation chelator encapsulated in a liposomal nanocarrier coated with apolipoprotein E (ApoE) to enhance brain targeting and copper chelation

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Block A, Schmelz E, Jones JB, Klee HJ

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However, due to the redundancy within antioxidant systems, complete inhibition via single targets remains challenging, and drug specificity must be optimized to avoid host toxicity

The sgRNA sequences were designed from the website ( These sgRNAs were cloned into plenti-CRISPR-V2 vectors