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Anemia In patients with end-stage kidney disease, anemia is induced by decreased production of erythropoietin by the kidney or fibrosis of the bone marrow

The relationship between dose and effect follows a sigmoid curve, meaning small potency losses at certain dose points might barely matter while the same percentage loss at other points could significantly reduce effectiveness

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Mobilization and protection

Dosing methionine alone or choline alone doesn't replicate the effect

Although cAMP is generally considered a positive signal for Ca 2+ mobilization, the present data indicated that elevated [Ca 2+ ] i is indispensable for insulin secretion