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As a result, scientists have developed numerous peptide-based medications with high receptor specificity, great pharmacokinetics, and favorable safety profiles [8]

reported for the first time that osteomalacia occurred in 4 patients who used phenytoin, primidone, and phenobarbitone for long-term antiseizure therapy, possibly because drug-mediated enzyme induction led to a significant increase in the degree of vitamin D inactivation (40)

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