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Neuromodulators, when used in TMJ treatment, help by relaxing the overactive jaw muscles responsible for bruxism
The failure of these treatments to restore function and slow functional disease progression can be traced to their inability to correct the underlying cause of the dysfunction- diminished synaptic connectivity among neurons in the striatum and neuronal loss in the substantia nigra (SN)
Nevertheless, this neoplasm is distinguished by its rapid propensity to invade the dermis, subsequently infiltrates the lymphatic pathways and extends to distant organs [41, 42]
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