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Native GIP produces full agonism of the human GIPR (half maximal effective concentration (EC 50 ) = 6.6 pM) and AMG 133 fully antagonizes native GIP (Extended Data Fig

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These protective niches facilitate survival during therapy and create conditions that favor relapse upon treatment cessation

Rat model of 3-NP toxicity Male Lewis rats (weighing 260-300g) fed with either an unsupplemented control diet or a diet supplemented with 2% creatine or 1% CoQ 10 or a combination of the two for one week were implanted subcutaneously with osmotic minipumps (Model 2ML1, Alzet, Cupertino CA, filled with 3-NP 70mg/ml in PBS, pH 7.4) that delivered 3-NP 50mg per kg bodyweight daily for 7 days while remaining on the same diets (Ouary et al

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