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TRIUMPH-4 is a phase 3, 68-week, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of retatrutide with placebo in adults with obesity or overweight and knee osteoarthritis
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this can be dangerous for people with overactive thyroids or those taking thyroid hormone replacement therapy
Impaired insulin signaling Insulin signaling plays a crucial role in maintaining peripheral nerve health, and its impairment significantly contributes to the pathogenesis of DPN
For instance, the rectal administration of taurocholic acid increased GLP-1 secretion in both healthy subjects [177] and obese type 2 diabetic volunteers [178]
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