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Due to the existence of the conjugated system of C = C bonds and carbonyl groups, 4-HNE can provide partial positive charge to the carbon at position three and become efficient electrophiles, allowing it to react with essential biological molecules, including proteins and DNA (107109)

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Oxidative stress can lead to the oxidation of low - density lipoprotein (LDL) cholesterol, a major factor in the development of atherosclerosis