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On the other hand, SUSTAIN-6 trial has found that subcutaneous semaglutide led to a 35% decrease in revascularization procedures, whether for coronary or peripheral vessels [55]

Lastly, upon streptozotocin-induced destruction of the -cells, there is an acute increase in islet PCSK1 and Gcg expression and increased processing of proglucagon to GLP-1 [158]

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