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doi: 10.1016/j.jtemb.2016.10.006 68 MahapatraDChattopadhyaySChandraAK
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Moreover, there is currently a lack of well-established biomarkers for ferroptosis, making it difficult to monitor in real time whether therapeutic agents have successfully activated ferroptosis pathways in clinical settings, which constitutes one of the major bottlenecks in clinical trial design (139)
Thus, these data indicate that functional Complex II and GPDH are sufficient for ROS production and subsequent induction of regulated cell death induced by supraphysiologic increases in the mitochondrial Q pool
Matrixyl has been evaluated in several double-blind, placebo-controlled studies showing reductions in wrinkle depth and improvements in skin texture
Ultimately, the choice of intervention may be guided by the clinical scenario, balancing immediacy of effect against durability
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