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7 GLP-1 RA Animal Studies Preclinical animal studies suggest that GLP-1 RAs have the potential to enhance autophagy, protect against mitochondrial stress, boost dopamine production, reduce neuronal loss and terminal denervation, and improve motor function

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2 Thus, there is a tremendous amount of research under way to further elucidate these mechanisms and, more important, to discover pharmacologically based strategies that correct these separate, but intertwined, physiologic derangements