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For orforglipron users, incorporating resistance training at least twice weekly is one of the most impactful complementary interventions available

A consistent, patient loading phase is almost always more effective

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Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

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