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Dose-ranging study of riluzole in amyotrophic lateral sclerosis

A GLP-1 Analog Lowers ER Stress and Enhances Protein Folding to Ameliorate Homocysteine-Induced Endothelial Dysfunction. Acta Pharmacologica Sinica, vol

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The enzyme is responsible for generating ROS by transferring electrons from NADPH to oxygen, which results in the formation of superoxide anion (O 2 ) [50, 51]

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This effect is currently being investigated in a phase 3 clinical trial (NCT04104321)