Actually, the nadir in colonic GSH content promoted by Amethopterin represents an alteration in the cellular redox state, suggesting that the cells could be more sensitive to reactive oxygen metabolites and leads to a reduction in the effectiveness of the antioxidant enzyme defense system [46, 47]
GPX4 and GSH levels were also reduced, suggesting that SH-SY5Y cell death by PQ plus maneb is associated with many of the features of ferroptosis
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Abstract Neurodegenerative diseases encompass a diverse array of disorders that have a profoundly detrimental impact on human health, characterized by their intricate and multifaceted pathogenesis
Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author