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The approval is based on the global ESSENCE trial, in which Wegovy demonstrated resolution of steatohepatitis in 63% of patients and reduction in liver fibrosis in 37% of patients

Malondialdehyde (MDA) and 4-hydroxy-nonenal (4-HNE) are the major products of lipid peroxidation (65)

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& Magnius, L

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus